Hypoxia and antitumor CD8(+) T cells: An incompatible alliance?

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Ressource 1Download: koni-05-12-1232236.pdf (826.73 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_78334F37BCC7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hypoxia and antitumor CD8(+) T cells: An incompatible alliance?
Journal
Oncoimmunology
Author(s)
Vuillefroy de Silly R., Dietrich P.Y., Walker P.R.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
5
Number
12
Pages
e1232236
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
T Lymphocytes face pathologically low O2 tensions within the tumor bed at which they will have to function in order to impact on the malignancy. Recent studies highlighting the importance of O2 and hypoxia-inducible factors for CD8(+) T-cell function and fate must now be integrated into tumor immunology concepts if immunotherapies are to progress. Here, we discuss, reinterpret, and reconcile the many apparent contradictions in these data and we propose that O2 is a master regulator of the CD8(+) T-cell response. Certain T cell functions are enhanced, others suppressed, but on balance, hypoxia is globally detrimental to the antitumor response.

Pubmed
Web of science
Create date
07/02/2017 18:37
Last modification date
20/08/2019 14:34
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