Evaluation of factors influencing <sup>18</sup>F-FET uptake in the brain.

Details

Ressource 1Download: 29159062_BIB_72246D66FD0C.pdf (750.28 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_72246D66FD0C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of factors influencing <sup>18</sup>F-FET uptake in the brain.
Journal
NeuroImage. Clinical
Author(s)
Verger A., Stegmayr C., Galldiks N., Van Der Gucht A., Lohmann P., Stoffels G., Shah N.J., Fink G.R., Eickhoff S.B., Guedj E., Langen K.J.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
17
Pages
491-497
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
PET using the amino-acid O-(2- <sup>18</sup> F-fluoroethyl)-l-tyrosine ( <sup>18</sup> F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of <sup>18</sup> F-FET uptake in various brain areas, and thus affect quantification of <sup>18</sup> F-FET uptake in brain tumours. Negative <sup>18</sup> F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of <sup>18</sup> F-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and volumes of interest (VOIs) analysis with fronto-parietal, temporal, occipital, and cerebellar SUV background areas were performed to study the effect of age, gender, height, weight, injected activity, body mass index (BMI), and body surface area (BSA). After multivariate analysis, female gender and high BMI were found to be two independent factors associated with increased SUV of <sup>18</sup> F-FET uptake in the brain. In women, SUV <sub>mean</sub> of <sup>18</sup> F-FET uptake in the brain was 23% higher than in men (p < 0.01). SUV <sub>mean</sub> of <sup>18</sup> F-FET uptake in the brain was positively correlated with BMI (r = 0.29; p < 0.01). The influence of these factors on SUV of <sup>18</sup> F-FET was similar in all brain areas. In conclusion, SUV of <sup>18</sup> F-FET in the normal brain is influenced by gender and weakly by BMI, but changes are similar in all brain areas.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Body Mass Index, Brain/diagnostic imaging, Brain/metabolism, Brain Neoplasms/diagnostic imaging, Brain Neoplasms/metabolism, Female, Humans, Male, Middle Aged, Positron-Emission Tomography/methods, Reference Standards, Retrospective Studies, Sex Factors, Tyrosine/analogs & derivatives, Tyrosine/pharmacokinetics, Young Adult, 18F-FET PET, BMI, Gender, Glioma, Quantitative analysis, SUV
Pubmed
Web of science
Open Access
Yes
Create date
23/11/2017 19:01
Last modification date
20/08/2019 14:30
Usage data