Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production.

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Serval ID
serval:BIB_71199D68E879
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production.
Journal
Journal of Experimental Medicine
Author(s)
Luther S.A., Gulbranson-Judge A., Acha-Orbea H., MacLennan I.C.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
1997
Volume
185
Number
3
Pages
551-562
Language
english
Abstract
Mouse mammary tumor virus (MMTV[SW]) encodes a superantigen expressed by infected B cells. It evokes an antibody response specific for viral envelope protein, indicating selective activation of antigen-specific B cells. The response to MMTV(SW) in draining lymph nodes was compared with the response to haptenated chicken gamma globulin (NP-CGG) using flow cytometry and immunohistology. T cell priming occurs in both responses, with T cells proliferating in association with interdigitating dendritic cells in the T zone. T cell proliferation continues in the presence of B cells in the outer T zone, and B blasts then undergo exponential growth and differentiation into plasma cells in the medullary cords. Germinal centers develop in both responses, but those induced by MMTV(SW) appear later and are smaller. Most T cells activated in the T zone and germinal centers in the MMTV(SW) response are superantigen specific and these persist for weeks in lymph nodes draining the site MMTV(SW) injection: this contrasts with the selective loss of superantigen-specific T cells from other secondary lymphoid tissues. The results indicate that this viral superantigen, when expressed by professional antigen-presenting cells, drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production.
Keywords
Animals, Antibodies, Viral/biosynthesis, B-Lymphocytes/physiology, Cell Differentiation, Chickens, Lymphocyte Activation, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Rats, Superantigens/physiology, T-Lymphocytes/physiology, gamma-Globulins/immunology
Pubmed
Web of science
Create date
24/01/2008 14:48
Last modification date
20/08/2019 14:29
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