The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

Doganci, A.; Eigenbrod, T.; Krug, N.; De Sanctis, G. T.; Hausding, M.; Erpenbeck, V. J.; Haddad, e.; Lehr, H. A.; Schmitt, E.; Bopp, T.; Kallen, K. J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J. M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M. F.; Galle, P. R.; Finotto, S.

doi:10.1172/JCI200522433

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

Details

Download: 15668741.pdf (1207.88 [Ko])
State: Public
Version: Final published version

Serval ID

serval:BIB_6F17D7494A33

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

Journal

Journal of Clinical Investigation

Author(s)

Doganci A., Eigenbrod T., Krug N., De Sanctis G. T., Hausding M., Erpenbeck V. J., Haddad e., Lehr H. A., Schmitt E., Bopp T., Kallen K. J., Herz U., Schmitt S., Luft C., Hecht O., Hohlfeld J. M., Ito H., Nishimoto N., Yoshizaki K., Kishimoto T., Rose-John S., Renz H., Neurath M. F., Galle P. R., Finotto S.

ISSN

0021-9738 (Print)

Publication state

Published

Issued date

2005

Volume

115

Number

Pages

313-325

Language

english

Notes

PT - Journal Article PT

Abstract

The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In this study, we investigated the role of IL-6R components in asthma. We observed increased levels of sIL-6R in the airways of patients with allergic asthma as compared to those in controls. In addition, local blockade of the sIL-6R in a murine model of late-phase asthma after OVA sensitization by gp130-fraction constant led to suppression of Th2 cells in the lung. By contrast, blockade of mIL-6R induced local expansion of Foxp3-positive CD4+CD25+ Tregs with increased immunosuppressive capacities. CD4+CD25+ but not CD4+

Keywords

Adult/Animals/Antibodies/administration & dosage/immunology/Asthma/Pathology/DNA-Binding Proteins/Female/Forkhead Transcription Factors/Homeodomain Proteins/genetics/Humans/Hypersensitivity/Inflammation/Lung/Male/Mice/Mice,Knockout/Ovalbumin/metabolism/Receptors,Cytokine/Receptors,Interleukin-2/Receptors,Interleukin-6/STAT3 Transcription Factor/Signal Transduction/drug effects/Th2 Cells/Trans-Activators

URN

urn:nbn:ch:serval-BIB_6F17D7494A335

OAI-PMH

oai:serval.unil.ch:BIB_6F17D7494A33

DOI

10.1172/JCI200522433

Pubmed

15668741

Web of science

000226867300016

Open Access

Yes