Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization.

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Serval ID
serval:BIB_6CCA5A0A9918
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization.
Journal
Frontiers in Immunology
Author(s)
Kypriotou M., Rivero D., Haller S., Mariotto A., Huber M., Acha-Orbea H., Werner S., Hohl D.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2013
Volume
4
Number
246
Pages
1-10
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish
Abstract
Activin A, a member of the TGFβ superfamily, is involved in physiological processes such as cell differentiation, tissue homeostasis, wound healing, reproduction, and in pathological conditions, such as fibrosis, cancer, and asthma. Activin enhances mast cell maturation, as well as regulatory T-cell and Langerhans cell differentiation. In this study we investigated the potential role of activin in epicutaneous sensitization with ovalbumin (OVA), notably with respect to its effect on known Th2-polarization. For this purpose, transgenic mice overexpressing activin in keratinocytes and their wild-type (WT) controls were sensitized epicutaneously with OVA. Skin biopsies were analyzed with regard to histopathological features and mRNA expression of pro-inflammatory and Th1/Th2 cytokines, and Ig levels were measured in the serum. Unexpectedly, activin overexpressing animals were protected from Th2-cytokine expression and induction of OVA-specific IgE levels compared to WT animals. On the other hand, transgenic mice were more susceptible to inflammation compared to WT littermates after tape-stripping and saline (vehicle) or OVA application, as shown by increased pro-inflammatory cytokine mRNA levels and neutrophil accumulation at the site of the treatment. We conclude that activin protects from antigen-induced cutaneous Th2-polarization through modulation of the immune response. These findings highlight the role of activin in cutaneous sensitization, allergy, and in skin homeostasis.
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2014 14:32
Last modification date
20/08/2019 14:26
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