New anthropometry-based age- and sex-specific reference values for urinary 24-hour creatinine excretion based on the adult Swiss population (epublish)

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Version: Final published version
Serval ID
serval:BIB_6C1E4D18FFDF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
New anthropometry-based age- and sex-specific reference values for urinary 24-hour creatinine excretion based on the adult Swiss population (epublish)
Journal
Bmc Medicine
Author(s)
Forni Ogna V., Ogna A., Vuistiner P., Pruijm M., Ponte B., Ackermann D., Gabutti L., Vakilzadeh N., Mohaupt M., Martin P.Y., Guessous I., Péchère-Bertschi A., Paccaud F., Bochud M., Burnier M.
Working group(s)
Swiss Survey on Salt Group
ISSN
1741-7015 (Electronic)
ISSN-L
1741-7015
Publication state
Published
Issued date
12/2015
Peer-reviewed
Oui
Volume
13
Number
1
Pages
40
Language
english
Notes
Publication Status: epublish
Abstract
BACKGROUND: Urinary creatinine excretion is used as a marker of completeness of timed urine collections, which are a keystone of several metabolic evaluations in clinical investigations and epidemiological surveys.
METHODS: We used data from two independent Swiss cross-sectional population-based studies with standardised 24-hour urinary collection and measured anthropometric variables. Only data from adults of European descent, with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 and reported completeness of the urinary collection were retained. A linear regression model was developed to predict centiles of the 24-hour urinary creatinine excretion in 1,137 participants from the Swiss Survey on Salt and validated in 994 participants from the Swiss Kidney Project on Genes in Hypertension.
RESULTS: The mean urinary creatinine excretion was 193 ± 41 μmol/kg/24 hours in men and 151 ± 38 μmol/kg/24 hours in women in the Swiss Survey on Salt. The values were inversely correlated with age and body mass index (BMI).
CONCLUSIONS: We propose a validated prediction equation for 24-hour urinary creatinine excretion in the general European population, based on readily available variables such as age, sex and BMI, and a few derived normograms to ease its clinical application. This should help healthcare providers to interpret the completeness of a 24-hour urine collection in daily clinical practice and in epidemiological population studies.
Pubmed
Web of science
Open Access
Yes
Create date
13/04/2015 11:42
Last modification date
20/08/2019 15:26
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