Vaccines as Priming Tools for T Cell Therapy for Epithelial Cancers.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_6B925EAAEE85
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Vaccines as Priming Tools for T Cell Therapy for Epithelial Cancers.
Journal
Cancers
Author(s)
Kandalaft L.E., Harari A.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
19/11/2021
Peer-reviewed
Oui
Volume
13
Number
22
Pages
5819
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Impressive progress has recently been made in the field of cancer immunotherapy with the adoptive transfer of T cells, a successful personalized strategy, and checkpoint inhibitors (CPI) having extended the survival of numerous patients. However, not all patients have been able to benefit from these innovations. A key determinant of the responsiveness to cancer immunotherapies is the presence of T cells within the tumors. These tumor-infiltrating lymphocytes (TILs) are crucial in controlling tumor growth and their activity is being potentiated by immunotherapies. Although some epithelial cancers are associated with spontaneous T-cell and B-cell responses, which makes them good candidates for immunotherapies, it remains to create strategies that would promote lymphocyte infiltration and enable sustained immune responses in immune-resistant tumors. Therapeutic cancer vaccines hold the potential of being able to render "cold", poorly infiltrated tumors into "hot" tumors that would be receptive to cellular immunotherapies. In this review, we elaborate on the obstacles that need to be overcome and the strategies that are being explored to that end, including various types of antigen repertoires and different vaccine platforms and combinations with other available treatments.
Keywords
dendritic cell, epithelial ovarian cancer, immunotherapy, personalized treatment, vaccines
Pubmed
Web of science
Open Access
Yes
Create date
03/12/2021 10:52
Last modification date
23/11/2022 7:11
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