Ammonia toxicity to the brain: effects on creatine metabolism and transport and protective roles of creatine.

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State: Public
Version: author
Serval ID
serval:BIB_6B88874CE224
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ammonia toxicity to the brain: effects on creatine metabolism and transport and protective roles of creatine.
Journal
Molecular genetics and metabolism
Author(s)
Braissant O.
ISSN
1096-7206 (Electronic)
ISSN-L
1096-7192
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
100 Suppl 1
Pages
S53-8
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hyperammonemia can provoke irreversible damage to the developing brain, with the formation of cortical atrophy, ventricular enlargement, demyelination or gray and white matter hypodensities. Among the various pathogenic mechanisms involved, alterations in cerebral energy have been demonstrated. In particular, we could show that ammonia exposure generates a secondary deficiency in creatine in brain cells, by altering the brain expression and activity of the genes allowing creatine synthesis (AGAT and GAMT) and transport (SLC6A8). On the other hand, it is known that creatine administration can exert protective effects in various neurodegenerative processes. We could also show that creatine co-treatment under ammonia exposure can protect developing brain cells from some of the deleterious effects of ammonia, in particular axonal growth impairment. This article focuses on the effects of ammonia exposure on creatine metabolism and transport in developing brain cells, and on the potential neuroprotective properties of creatine in the brain exposed to ammonium.

Keywords
Ammonia/toxicity, Animals, Axons/drug effects, Axons/metabolism, Biological Transport/drug effects, Brain/drug effects, Brain/enzymology, Brain/pathology, Cell Culture Techniques, Creatine/metabolism, Humans, Models, Biological, Protective Agents/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
26/02/2010 8:38
Last modification date
20/08/2019 14:25
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