Normal values for pancreatic stone protein in different age groups.

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Version: Final published version
Serval ID
serval:BIB_69F33CAB52E5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Normal values for pancreatic stone protein in different age groups.
Journal
Bmc Anesthesiology
Author(s)
Schlapbach L.J., Giannoni E., Wellmann S., Stocker M., Ammann R.A., Graf R.
ISSN
1471-2253 (Electronic)
ISSN-L
1471-2253
Publication state
Published
Issued date
2015
Volume
15
Pages
168
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
BACKGROUND: Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP.
METHODS: PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations.
RESULTS: PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %).
CONCLUSIONS: This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood.
Keywords
Adolescent, Adult, Age Factors, Biomarkers/blood, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Infant, Newborn, Lithostathine/blood, Male, Middle Aged, Reference Values, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
05/12/2015 12:32
Last modification date
20/08/2019 14:24
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