Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells.

Details

Ressource 1Download: elife-23612-v2.pdf (3692.38 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_622287211E88
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells.
Journal
eLife
Author(s)
Li L., Sultan S., Heigele S., Schmidt-Salzmann C., Toni N., Bischofberger J.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
08/08/2017
Peer-reviewed
Oui
Volume
6
Pages
e23612
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
In adult neurogenesis young neurons connect to the existing network via formation of thousands of new synapses. At early developmental stages, glutamatergic synapses are sparse, immature and functionally 'silent', expressing mainly NMDA receptors. Here we show in 2- to 3-week-old young neurons of adult mice, that brief-burst activity in glutamatergic fibers is sufficient to induce postsynaptic AP firing in the absence of AMPA receptors. The enhanced excitability of the young neurons lead to efficient temporal summation of small NMDA currents, dynamic unblocking of silent synapses and NMDA-receptor-dependent AP firing. Therefore, early synaptic inputs are powerfully converted into reliable spiking output. Furthermore, due to high synaptic gain, small dendritic trees and sparse connectivity, neighboring young neurons are activated by different distinct subsets of afferent fibers with minimal overlap. Taken together, synaptic recruitment of young neurons generates sparse and orthogonal AP firing, which may support sparse coding during hippocampal information processing.
Keywords
Action Potentials/drug effects, Action Potentials/physiology, Aging/physiology, Animals, Cytoplasmic Granules/drug effects, Cytoplasmic Granules/metabolism, Dendrites/drug effects, Dendrites/metabolism, Excitatory Postsynaptic Potentials/physiology, Glutamates/metabolism, Hippocampus/cytology, Male, Mice, Inbred C57BL, N-Methylaspartate/pharmacology, Neurogenesis/drug effects, Presynaptic Terminals/drug effects, Presynaptic Terminals/metabolism, Receptors, N-Methyl-D-Aspartate/metabolism, Synapses/drug effects, Synapses/physiology, Time Factors, NMDA receptor signaling, adult neurogenesis, hippocampus, mouse, neuroscience, silent synapses, synapse formation, synaptic transmission
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2017 13:35
Last modification date
20/08/2019 14:19
Usage data