Concise reviews: in vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.

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Version: author
Serval ID
serval:BIB_601729A47CA2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Concise reviews: in vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.
Journal
Stem Cells
Author(s)
Greggio C., De Franceschi F., Grapin-Botton A.
ISSN
1549-4918 (Electronic)
ISSN-L
1066-5099
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
33
Number
1
Pages
8-14
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Three-dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of cells. Such models allow the formation of miniature organs in a dish and are emerging for the pancreas, starting from embryonic progenitors and adult cells. This review focuses on the currently available systems and how these allow new types of questions to be addressed. We discuss the expected advancements including their potential to study human pancreas development and function as well as to develop diabetes models and therapeutic cells.
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2015 11:03
Last modification date
20/08/2019 14:17
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