Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth.

Details

Ressource 1Download: BIB_6008DD9E3699.P001.pdf (743.00 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_6008DD9E3699
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth.
Journal
Oncogene
Author(s)
Fritz V., Benfodda Z., Henriquet C., Hure S., Cristol J.P., Michel F., Carbonneau M.A., Casas F., Fajas L.
ISSN
1476-5594 (Electronic)
ISSN-L
0950-9232
Publication state
Published
Issued date
2013
Volume
32
Number
42
Pages
5101-5110
Language
english
Abstract
One of the most conserved features of all cancers is a profound reprogramming of cellular metabolism, favoring biosynthetic processes and limiting catalytic processes. With the acquired knowledge of some of these important changes, we have designed a combination therapy in order to force cancer cells to use a particular metabolic pathway that ultimately results in the accumulation of toxic products. This innovative approach consists of blocking lipid synthesis, at the same time that we force the cell, through the inhibition of AMP-activated kinase, to accumulate toxic intermediates, such as malonyl-coenzyme A (malonyl-CoA) or nicotinamide adenine dinucleotide phosphate. This results in excess of oxidative stress and cancer cell death. Our new therapeutic strategy, based on the manipulation of metabolic pathways, will certainly set up the basis for new upcoming studies defining a new paradigm of cancer treatment.
Pubmed
Web of science
Open Access
Yes
Create date
17/11/2013 18:19
Last modification date
20/08/2019 14:17
Usage data