The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture.

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Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture.
Journal
Nucleic Acids Research
Author(s)
Dorier J., Stasiak A.
ISSN
1362-4962[electronic], 0305-1048[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
38
Number
21
Pages
7410-7421
Language
english
Abstract
Using numerical simulations, we investigate the underlying physical effects responsible for the overall organization of chromosomal territories in interphase nuclei. In particular, we address the following three questions: (i) why are chromosomal territories with relatively high transcriptional activity on average, closer to the centre of cell's nucleus than those with the lower activity? (ii) Why are actively transcribed genes usually located at the periphery of their chromosomal territories? (iii) Why are pair-wise contacts between active and inactive genes less frequent than those involving only active or only inactive genes? We show that transcription factories-mediated contacts between active genes belonging to different chromosomal territories are instrumental for all these features of nuclear organization to emerge spontaneously due to entropic effects arising when chromatin fibres are highly crowded.
Keywords
Chromosomes/genetics, Chromosomes/ultrastructure, Models, Genetic, Transcription, Genetic
Pubmed
Web of science
Open Access
Yes
Create date
12/11/2010 18:35
Last modification date
20/08/2019 14:15
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