Common variants associated with plasma triglycerides and risk for coronary artery disease.

Do, R.; Willer, C.J.; Schmidt, E.M.; Sengupta, S.; Gao, C.; Peloso, G.M.; Gustafsson, S.; Kanoni, S.; Ganna, A.; Chen, J.; Buchkovich, M.L.; Mora, S.; Beckmann, J.S.; Bragg-Gresham, J.L.; Chang, H.Y.; Demirkan, A.; Den Hertog, H.M.; Donnelly, L.A.; Ehret, G.B.; Esko, T.; Feitosa, M.F.; Ferreira, T.; Fischer, K.; Fontanillas, P.; Fraser, R.M.; Freitag, D.F.; Gurdasani, D.; Heikkilä, K.; Hyppönen, E.; Isaacs, A.; Jackson, A.U.; Johansson, A.; Johnson, T.; Kaakinen, M.; Kettunen, J.; Kleber, M.E.; Li, X.; Luan, J.; Lyytikäinen, L.P.; Magnusson, P.K.; Mangino, M.; Mihailov, E.; Montasser, M.E.; Müller-Nurasyid, M.; Nolte, I.M.; O'Connell, J.R.; Palmer, C.D.; Perola, M.; Petersen, A.K.; Sanna, S.; Saxena, R.; Service, S.K.; Shah, S.; Shungin, D.; Sidore, C.; Song, C.; Strawbridge, R.J.; Surakka, I.; Tanaka, T.; Teslovich, T.M.; Thorleifsson, G.; Van den Herik, E.G.; Voight, B.F.; Volcik, K.A.; Waite, L.L.; Wong, A.; Wu, Y.; Zhang, W.; Absher, D.; Asiki, G.; Barroso, I.; Been, L.F.; Bolton, J.L.; Bonnycastle, L.L.; Brambilla, P.; Burnett, M.S.; Cesana, G.; Dimitriou, M.; Doney, A.S.; Döring, A.; Elliott, P.; Epstein, S.E.; Eyjolfsson, G.I.; Gigante, B.; Goodarzi, M.O.; Grallert, H.; Gravito, M.L.; Groves, C.J.; Hallmans, G.; Hartikainen, A.L.; Hayward, C.; Hernandez, D.; Hicks, A.A.; Holm, H.; Hung, Y.J.; Illig, T.; Jones, M.R.; Kaleebu, P.; Kastelein, J.J.; Khaw, K.T.; Kim, E.; Klopp, N.; Komulainen, P.; Kumari, M.; Langenberg, C.; Lehtimäki, T.; Lin, S.Y.; Lindström, J.; Loos, R.J.; Mach, F.; McArdle, W.L.; Meisinger, C.; Mitchell, B.D.; Müller, G.; Nagaraja, R.; Narisu, N.; Nieminen, T.V.; Nsubuga, R.N.; Olafsson, I.; Ong, K.K.; Palotie, A.; Papamarkou, T.; Pomilla, C.; Pouta, A.; Rader, D.J.; Reilly, M.P.; Ridker, P.M.; Rivadeneira, F.; Rudan, I.; Ruokonen, A.; Samani, N.; Scharnagl, H.; Seeley, J.; Silander, K.; Stančáková, A.; Stirrups, K.; Swift, A.J.; Tiret, L.; Uitterlinden, A.G.; van Pelt, L.J.; Vedantam, S.; Wainwright, N.; Wijmenga, C.; Wild, S.H.; Willemsen, G.; Wilsgaard, T.; Wilson, J.F.; Young, E.H.; Zhao, J.H.; Adair, L.S.; Arveiler, D.; Assimes, T.L.; Bandinelli, S.; Bennett, F.; Bochud, M.; Boehm, B.O.; Boomsma, D.I.; Borecki, I.B.; Bornstein, S.R.; Bovet, P.; Burnier, M.; Campbell, H.; Chakravarti, A.; Chambers, J.C.; Chen, Y.D.; Collins, F.S.; Cooper, R.S.; Danesh, J.; Dedoussis, G.; de Faire, U.; Feranil, A.B.; Ferrières, J.; Ferrucci, L.; Freimer, N.B.; Gieger, C.; Groop, L.C.; Gudnason, V.; Gyllensten, U.; Hamsten, A.; Harris, T.B.; Hingorani, A.; Hirschhorn, J.N.; Hofman, A.; Hovingh, G.K.; Hsiung, C.A.; Humphries, S.E.; Hunt, S.C.; Hveem, K.; Iribarren, C.; Järvelin, M.R.; Jula, A.; Kähönen, M.; Kaprio, J.; Kesäniemi, A.; Kivimaki, M.; Kooner, J.S.; Koudstaal, P.J.; Krauss, R.M.; Kuh, D.; Kuusisto, J.; Kyvik, K.O.; Laakso, M.; Lakka, T.A.; Lind, L.; Lindgren, C.M.; Martin, N.G.; März, W.; McCarthy, M.I.; McKenzie, C.A.; Meneton, P.; Metspalu, A.; Moilanen, L.; Morris, A.D.; Munroe, P.B.; Njølstad, I.; Pedersen, N.L.; Power, C.; Pramstaller, P.P.; Price, J.F.; Psaty, B.M.; Quertermous, T.; Rauramaa, R.; Saleheen, D.; Salomaa, V.; Sanghera, D.K.; Saramies, J.; Schwarz, P.E.; Sheu, W.H.; Shuldiner, A.R.; Siegbahn, A.; Spector, T.D.; Stefansson, K.; Strachan, D.P.; Tayo, B.O.; Tremoli, E.; Tuomilehto, J.; Uusitupa, M.; van Duijn, C.M.; Vollenweider, P.; Wallentin, L.; Wareham, N.J.; Whitfield, J.B.; Wolffenbuttel, B.H.; Altshuler, D.; Ordovas, J.M.; Boerwinkle, E.; Palmer, C.N.; Thorsteinsdottir, U.; Chasman, D.I.; Rotter, J.I.; Franks, P.W.; Ripatti, S.; Cupples, L.A.; Sandhu, M.S.; Rich, S.S.; Boehnke, M.; Deloukas, P.; Mohlke, K.L.; Ingelsson, E.; Abecasis, G.R.; Daly, M.J.; Neale, B.M.; Kathiresan, S.

doi:10.1038/ng.2795

Common variants associated with plasma triglycerides and risk for coronary artery disease.

Details

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Serval ID

serval:BIB_5CA22C7D515E

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Common variants associated with plasma triglycerides and risk for coronary artery disease.

Journal

Nature Genetics

Author(s)

Do R., Willer C.J., Schmidt E.M., Sengupta S., Gao C., Peloso G.M., Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich M.L., Mora S., Beckmann J.S., Bragg-Gresham J.L., Chang H.Y., Demirkan A., Den Hertog H.M., Donnelly L.A., Ehret G.B., Esko T., Feitosa M.F., Ferreira T., Fischer K., Fontanillas P., Fraser R.M., Freitag D.F., Gurdasani D., Heikkilä K., Hyppönen E., Isaacs A., Jackson A.U., Johansson A., Johnson T., Kaakinen M., Kettunen J., Kleber M.E., Li X., Luan J., Lyytikäinen L.P., Magnusson P.K., Mangino M., Mihailov E., Montasser M.E., Müller-Nurasyid M., Nolte I.M., O'Connell J.R., Palmer C.D., Perola M., Petersen A.K., Sanna S., Saxena R., Service S.K., Shah S., Shungin D., Sidore C., Song C., Strawbridge R.J., Surakka I., Tanaka T., Teslovich T.M., Thorleifsson G., Van den Herik E.G., Voight B.F., Volcik K.A., Waite L.L., Wong A., Wu Y., Zhang W., Absher D., Asiki G., Barroso I., Been L.F., Bolton J.L., Bonnycastle L.L., Brambilla P., Burnett M.S., Cesana G., Dimitriou M., Doney A.S., Döring A., Elliott P., Epstein S.E., Eyjolfsson G.I., Gigante B., Goodarzi M.O., Grallert H., Gravito M.L., Groves C.J., Hallmans G., Hartikainen A.L., Hayward C., Hernandez D., Hicks A.A., Holm H., Hung Y.J., Illig T., Jones M.R., Kaleebu P., Kastelein J.J., Khaw K.T., Kim E., Klopp N., Komulainen P., Kumari M., Langenberg C., Lehtimäki T., Lin S.Y., Lindström J., Loos R.J., Mach F., McArdle W.L., Meisinger C., Mitchell B.D., Müller G., Nagaraja R., Narisu N., Nieminen T.V., Nsubuga R.N., Olafsson I., Ong K.K., Palotie A., Papamarkou T., Pomilla C., Pouta A., Rader D.J., Reilly M.P., Ridker P.M., Rivadeneira F., Rudan I., Ruokonen A., Samani N., Scharnagl H., Seeley J., Silander K., Stančáková A., Stirrups K., Swift A.J., Tiret L., Uitterlinden A.G., van Pelt L.J., Vedantam S., Wainwright N., Wijmenga C., Wild S.H., Willemsen G., Wilsgaard T., Wilson J.F., Young E.H., Zhao J.H., Adair L.S., Arveiler D., Assimes T.L., Bandinelli S., Bennett F., Bochud M., Boehm B.O., Boomsma D.I., Borecki I.B., Bornstein S.R., Bovet P., Burnier M., Campbell H., Chakravarti A., Chambers J.C., Chen Y.D., Collins F.S., Cooper R.S., Danesh J., Dedoussis G., de Faire U., Feranil A.B., Ferrières J., Ferrucci L., Freimer N.B., Gieger C., Groop L.C., Gudnason V., Gyllensten U., Hamsten A., Harris T.B., Hingorani A., Hirschhorn J.N., Hofman A., Hovingh G.K., Hsiung C.A., Humphries S.E., Hunt S.C., Hveem K., Iribarren C., Järvelin M.R., Jula A., Kähönen M., Kaprio J., Kesäniemi A., Kivimaki M., Kooner J.S., Koudstaal P.J., Krauss R.M., Kuh D., Kuusisto J., Kyvik K.O., Laakso M., Lakka T.A., Lind L., Lindgren C.M., Martin N.G., März W., McCarthy M.I., McKenzie C.A., Meneton P., Metspalu A., Moilanen L., Morris A.D., Munroe P.B., Njølstad I., Pedersen N.L., Power C., Pramstaller P.P., Price J.F., Psaty B.M., Quertermous T., Rauramaa R., Saleheen D., Salomaa V., Sanghera D.K., Saramies J., Schwarz P.E., Sheu W.H., Shuldiner A.R., Siegbahn A., Spector T.D., Stefansson K., Strachan D.P., Tayo B.O., Tremoli E., Tuomilehto J., Uusitupa M., van Duijn C.M., Vollenweider P., Wallentin L., Wareham N.J., Whitfield J.B., Wolffenbuttel B.H., Altshuler D., Ordovas J.M., Boerwinkle E., Palmer C.N., Thorsteinsdottir U., Chasman D.I., Rotter J.I., Franks P.W., Ripatti S., Cupples L.A., Sandhu M.S., Rich S.S., Boehnke M., Deloukas P., Mohlke K.L., Ingelsson E., Abecasis G.R., Daly M.J., Neale B.M., Kathiresan S.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

2013

Volume

Number

Pages

1345-1352

Language

english

Notes

Publication types: Journal ArticlePublication Status: ppublish. pdf type: letter as journal article (Nature Genetics)

Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

URN

urn:nbn:ch:serval-BIB_5CA22C7D515E7

OAI-PMH

oai:serval.unil.ch:BIB_5CA22C7D515E

DOI

10.1038/ng.2795

Pubmed

24097064

Web of science

000326384100015

Create date

10/12/2013 11:43