Blood proteome of acute intracranial hemorrhage in infant victims of abusive head trauma.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_55A9C6918506
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood proteome of acute intracranial hemorrhage in infant victims of abusive head trauma.
Journal
Proteomics
Author(s)
Wiskott K., Gilardi F., Hainard A., Sanchez J.C., Thomas A., Sajic T., Fracasso T.
ISSN
1615-9861 (Electronic)
ISSN-L
1615-9853
Publication state
Published
Issued date
02/2023
Peer-reviewed
Oui
Volume
23
Number
3-4
Pages
e2200078
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Abusive head trauma (AHT) is a leading cause of mortality and morbidity in infants. While the reported incidence is close to 40 cases per 100'000 births/year, misdiagnoses are commonly observed in cases with atypical, subacute, or chronic presentation. Currently, standard clinical evaluation of inflicted intracranial hemorrhagic injury (ICH) in infants urgently requires a screening test able to identify infants who need additional investigations. Blood biomarkers characteristic of AHT may assist in detecting these infants, improving prognosis through early medical care. To date, the application of innovative omics technologies in retrospective studies of AHT in infants is rare, due also to the blood serum and cerebrospinal fluid of AHT cases being scarce and not systematically accessible. Here, we explored the circulating blood proteomes of infants with severe AHT and their atraumatic controls. We discovered 165 circulating serum proteins that display differential changes in AHT cases compared with atraumatic controls. The peripheral blood proteomes of pediatric AHT commonly reflect: (i) potentially secreted proteome from injured brain, and (ii) proteome dysregulated in the system's circulation by successive biological events following acute ICH. This study opens up a novel opportunity for research efforts in clinical screening of AHT cases.
Keywords
Humans, Infant, Child, Proteome, Retrospective Studies, Child Abuse/diagnosis, Craniocerebral Trauma/diagnosis, Craniocerebral Trauma/epidemiology, Intracranial Hemorrhages/diagnosis, pediatric abusive head trauma, postmortem blood, serum proteomics
Pubmed
Web of science
Open Access
Yes
Create date
03/01/2023 15:05
Last modification date
01/03/2023 6:47
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