X-chromosome SNP analyses in 11 human Mediterranean populations show a high overall genetic homogeneity except in North-west Africans (Moroccans).

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Version: Final published version
Serval ID
serval:BIB_4C6AAC7319D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
X-chromosome SNP analyses in 11 human Mediterranean populations show a high overall genetic homogeneity except in North-west Africans (Moroccans).
Journal
BMC evolutionary biology
Author(s)
Tomas C., Sanchez J.J., Barbaro A., Brandt-Casadevall C., Hernandez A., Ben Dhiab M., Ramon M., Morling N.
ISSN
1471-2148 (Electronic)
ISSN-L
1471-2148
Publication state
Published
Issued date
29/02/2008
Peer-reviewed
Oui
Volume
8
Pages
75
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Due to its history, with a high number of migration events, the Mediterranean basin represents a challenging area for population genetic studies. A large number of genetic studies have been carried out in the Mediterranean area using different markers but no consensus has been reached on the genetic landscape of the Mediterranean populations. In order to further investigate the genetics of the human Mediterranean populations, we typed 894 individuals from 11 Mediterranean populations with 25 single-nucleotide polymorphisms (SNPs) located on the X-chromosome.
A high overall homogeneity was found among the Mediterranean populations except for the population from Morocco, which seemed to differ genetically from the rest of the populations in the Mediterranean area. A very low genetic distance was found between populations in the Middle East and most of the western part of the Mediterranean Sea.A higher migration rate in females versus males was observed by comparing data from X-chromosome, mt-DNA and Y-chromosome SNPs both in the Mediterranean and a wider geographic area.Multilocus association was observed among the 25 SNPs on the X-chromosome in the populations from Ibiza and Cosenza.
Our results support both the hypothesis of (1) a reduced impact of the Neolithic Wave and more recent migration movements in NW-Africa, and (2) the importance of the Strait of Gibraltar as a geographic barrier. In contrast, the high genetic homogeneity observed in the Mediterranean area could be interpreted as the result of the Neolithic wave caused by a large demic diffusion and/or more recent migration events. A differentiated contribution of males and females to the genetic landscape of the Mediterranean area was observed with a higher migration rate in females than in males. A certain level of background linkage disequilibrium in populations in Ibiza and Cosenza could be attributed to their demographic background.

Keywords
African Continental Ancestry Group/genetics, Analysis of Variance, Chromosomes, Human, X/genetics, Chromosomes, Human, Y/genetics, Cluster Analysis, DNA, Mitochondrial/genetics, Emigration and Immigration, Gene Frequency, Genetic Markers/genetics, Genetic Variation, Genetics, Population, Humans, Male, Morocco, Polymorphism, Single Nucleotide
Pubmed
Web of science
Open Access
Yes
Create date
28/03/2009 10:27
Last modification date
20/08/2019 14:00
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