Apoptotic markers in protozoan parasites.

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Serval ID
serval:BIB_42C7F8FDC79A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Apoptotic markers in protozoan parasites.
Journal
Parasites and Vectors
Author(s)
Jiménez-Ruiz A., Alzate J.F., Macleod E.T., Lüder C.G., Fasel N., Hurd H.
ISSN
1756-3305[electronic], 1756-3305[linking]
Publication state
Published
Issued date
2010
Volume
3
Pages
104
Language
english
Abstract
ABSTRACT: The execution of the apoptotic death program in metazoans is characterized by a sequence of morphological and biochemical changes that include cell shrinkage, presentation of phosphatidylserine at the cell surface, mitochondrial alterations, chromatin condensation, nuclear fragmentation, membrane blebbing and the formation of apoptotic bodies. Methodologies for measuring apoptosis are based on these markers. Except for membrane blebbing and formation of apoptotic bodies, all other events have been observed in most protozoan parasites undergoing cell death. However, while techniques exist to detect these markers, they are often optimised for metazoan cells and therefore may not pick up subtle differences between the events occurring in unicellular organisms and multi-cellular organisms.In this review we discuss the markers most frequently used to analyze cell death in protozoan parasites, paying special attention to changes in cell morphology, mitochondrial activity, chromatin structure and plasma membrane structure/permeability. Regarding classical regulators/executors of apoptosis, we have reviewed the present knowledge of caspase-like and nuclease activities.
Keywords
PROGRAMMED CELL-DEATH, LEISHMANIA-DONOVANI PROMASTIGOTES, TRYPANOSOMA-BRUCEI-RHODESIENSE, MILTEFOSINE INDUCES APOPTOSIS, ASEXUAL BLOOD STAGES, BCL-X-L, PLASMODIUM-FALCIPARUM, DNA FRAGMENTATION, BLASTOCYSTIS-HOMINIS, FEBRILE TEMPERATURE
Pubmed
Web of science
Open Access
Yes
Create date
03/02/2011 10:39
Last modification date
20/08/2019 13:45
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