A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.

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State: Public
Version: Final published version
Serval ID
serval:BIB_420B9930D181
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.
Journal
Frontiers in Cellular Neuroscience
Author(s)
Elsayed M., Magistretti P.J.
ISSN
1662-5102 (Electronic)
ISSN-L
1662-5102
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
9
Pages
468
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: epublishDocument Type: Review
Abstract
Mental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines of evidence suggest more diverse and significant functions of glia with behavior-altering effects. The newly ascribed roles of astrocytes, oligodendrocytes and microglia have led to their examination in brain pathology and mental illnesses. Indeed, abnormalities in glial function, structure and density have been observed in postmortem brain studies of subjects diagnosed with mental illnesses. In this review, we discuss the newly identified functions of glia and highlight the findings of glial abnormalities in psychiatric disorders. We discuss these preclinical and clinical findings implicating the involvement of glial cells in mental illnesses with the perspective that these cells may represent a new target for treatment.
Keywords
psychiatric disorder, glia, astrocyte, oligodendrocyte, microglia, NG2 glia, mood, cognition
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2016 17:28
Last modification date
16/02/2021 6:27
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