Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Warren, H.R.; Evangelou, E.; Cabrera, C.P.; Gao, H.; Ren, M.; Mifsud, B.; Ntalla, I.; Surendran, P.; Liu, C.; Cook, J.P.; Kraja, A.T.; Drenos, F.; Loh, M.; Verweij, N.; Marten, J.; Karaman, I.; Lepe, M.P.; O'Reilly, P.F.; Knight, J.; Snieder, H.; Kato, N.; He, J.; Tai, E.S.; Said, M.A.; Porteous, D.; Alver, M.; Poulter, N.; Farrall, M.; Gansevoort, R.T.; Padmanabhan, S.; Mägi, R.; Stanton, A.; Connell, J.; Bakker, S.J.; Metspalu, A.; Shields, D.C.; Thom, S.; Brown, M.; Sever, P.; Esko, T.; Hayward, C.; van der Harst, P.; Saleheen, D.; Chowdhury, R.; Chambers, J.C.; Chasman, D.I.; Chakravarti, A.; Newton-Cheh, C.; Lindgren, C.M.; Levy, D.; Kooner, J.S.; Keavney, B.; Tomaszewski, M.; Samani, N.J.; Howson, J.M.; Tobin, M.D.; Munroe, P.B.; Ehret, G.B.; Wain, L.V.

doi:10.1038/ng.3768

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Details

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State: Public
Version: Author's accepted manuscript
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Serval ID

serval:BIB_3DE32D5D8A36

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Journal

Nature genetics

Author(s)

Warren H.R., Evangelou E., Cabrera C.P., Gao H., Ren M., Mifsud B., Ntalla I., Surendran P., Liu C., Cook J.P., Kraja A.T., Drenos F., Loh M., Verweij N., Marten J., Karaman I., Lepe M.P., O'Reilly P.F., Knight J., Snieder H., Kato N., He J., Tai E.S., Said M.A., Porteous D., Alver M., Poulter N., Farrall M., Gansevoort R.T., Padmanabhan S., Mägi R., Stanton A., Connell J., Bakker S.J., Metspalu A., Shields D.C., Thom S., Brown M., Sever P., Esko T., Hayward C., van der Harst P., Saleheen D., Chowdhury R., Chambers J.C., Chasman D.I., Chakravarti A., Newton-Cheh C., Lindgren C.M., Levy D., Kooner J.S., Keavney B., Tomaszewski M., Samani N.J., Howson J.M., Tobin M.D., Munroe P.B., Ehret G.B., Wain L.V.

Working group(s)

International Consortium of Blood Pressure (ICBP) 1000G Analyses, BIOS Consortium, Lifelines Cohort Study, Understanding Society Scientific group, CHD Exome+ Consortium, ExomeBP Consortium, T2D-GENES Consortium, GoT2DGenes Consortium, Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, UK Biobank CardioMetabolic Consortium BP working group

Contributor(s)

Völker U., Vollenweider P., Wild S., Willemsen G., Wright A.F., Yao J., Thériault S., Conen D., John A., Sever P., Debette S., Mook-Kanamori D.O., Zeggini E., Spector T.D., van der Harst P., Palmer C.N., Vergnaud A.C., Loos R.J., Polasek O., Starr J.M., Girotto G., Hayward C., Kooner J.S., Lindgren C.M., Vitart V., Samani N.J., Tuomilehto J., Gyllensten U., Knekt P., Deary I.J., Ciullo M., Elosua R., Keavney B.D., Hicks A.A., Scott R.A., Gasparini P., Laan M., Liu Y., Watkins H., Hartman C.A., Salomaa V., Toniolo D., Perola M., Wilson J.F., Schmidt H., Zhao J.H., Lehtimäki T., van Duijn C.M., Gudnason V., Psaty B.M., Peters A., Rettig R., James A., Jukema J.W., Strachan D.P., Palmas W., Metspalu A., Ingelsson E., Boomsma D.I., Franco O.H., Bochud M., Newton-Cheh C., Munroe P.B., Elliott P., Chasman D.I., Chakravarti A., Knight J., Morris A.P., Levy D., Tobin M.D., Snieder H., Caulfield M.J., Ehret G.B., Barnes M.R., Tzoulaki I., Caulfield M.J., Elliott P.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

04/2017

Peer-reviewed

Oui

Volume

Number

Pages

403-415

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

URN

urn:nbn:ch:serval-BIB_3DE32D5D8A366

OAI-PMH

oai:serval.unil.ch:BIB_3DE32D5D8A36

DOI

10.1038/ng.3768

Pubmed

28135244

Web of science

000394917800014

Create date

03/04/2017 18:12