Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect.

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serval:BIB_38A645DFEB16
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect.
Journal
Environmental Health Perspectives
Author(s)
Imboden M., Schwartz J., Schindler C., Curjuric I., Berger W., Liu S.L., Russi E.W., Ackermann-Liebrich U., Rochat T., Probst-Hensch N.M., SAPALDIA Team
Contributor(s)
SAPALDIA Team, Ackermann-Liebrich U., Gaspoz JM., Leuenberger P., Liu LJ., Probst-Hensch NM., Schindler C., Rochat T., Barthélémy JC., Berger W., Bettschart R., Bircher A., Bolognini G., Brändli O., Brutsche M., Burdet L., Frey M., Gerbase MW., Gold D., Karrer W., Keller R., Knöpfli B., Künzli N., Neu U., Nicod L., Pons M., Russi E., Schmid-Grendelmeyer P., Schwartz J., Straehl P., Tschopp JM., von Eckardstein A., Zellweger JP., Zemp Stutz E., Bridevaux PO., Curjuric I., Dratva J., Felber Dietrich D., Keidel D., Imboden M., Phuleria H., Schaffner E., Thun GA.
ISSN
1552-9924 (Electronic)
ISSN-L
0091-6765
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
117
Number
9
Pages
1420-1427
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution.
OBJECTIVE: We determined in 4,326 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) whether four single-nucleotide polymorphisms in three genes [CCND1 (rs9344 [P242P], rs667515), p53 (rs1042522 [R72P]), and p21 (rs1801270 [S31R])] modified the previously observed attenuation of the decline in the forced expiratory flow between 25% and 75% of the forced vital capacity (FEF(25-75)) associated with improved air quality.
METHODS: Subjects of the prospective population-based SAPALDIA cohort were assessed in 1991 and 2002 by spirometry, questionnaires, and biological sample collection for genotyping. We assigned spatially resolved concentrations of particulate matter with aerodynamic diameter < or = 10 microm (PM(10)) to each participant's residential history 12 months before the baseline and follow-up assessments.
RESULTS: The effect of diminishing PM(10) exposure on FEF(25-75) decline appeared to be modified by p53 R72P, CCND1 P242P, and CCND1 rs667515. For example, a 10-microg/m(3) decline in average PM(10) exposure over an 11-year period attenuated the average annual decline in FEF(25-75) by 21.33 mL/year (95% confidence interval, 10.57-32.08) among participants homozygous for the CCND1 (P242P) GG genotype, by 13.72 mL/year (5.38-22.06) among GA genotypes, and by 6.00 mL/year (-4.54 to 16.54) among AA genotypes.
CONCLUSIONS: Our results suggest that cell cycle control genes may modify the degree to which improved air quality may benefit respiratory function in adults.
Keywords
Adult, Air Pollutants/toxicity, Base Sequence, Cohort Studies, Cyclin D1/genetics, DNA Primers, Female, Genes, p53, Genetic Variation, Humans, Lung/drug effects, Lung/physiology, Male, Particle Size, Proto-Oncogene Proteins p21(ras)/genetics, Respiratory Function Tests
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Web of science
Create date
20/10/2009 9:23
Last modification date
20/08/2019 13:28
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