The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy.

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State: Public
Version: Final published version
Serval ID
serval:BIB_37EE9102829A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy.
Journal
NeuroImage. Clinical
Author(s)
Oltedal L., Bartsch H., Sørhaug O.J., Kessler U., Abbott C., Dols A., Stek M.L., Ersland L., Emsell L., van Eijndhoven P., Argyelan M., Tendolkar I., Nordanskog P., Hamilton P., Jorgensen M.B., Sommer I.E., Heringa S.M., Draganski B., Redlich R., Dannlowski U., Kugel H., Bouckaert F., Sienaert P., Anand A., Espinoza R., Narr K.L., Holland D., Dale A.M., Oedegaard K.J.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
14
Pages
422-432
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches.

Keywords
Electroconvulsive therapy, Longitudinal, MRI, Mega analysis, Multi-site
Pubmed
Web of science
Open Access
Yes
Create date
21/03/2017 19:12
Last modification date
20/08/2019 13:26
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