A key transcription cofactor on the nascent sex chromosomes of European tree frogs (Hyla arborea)

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Serval ID
serval:BIB_33B31B102586
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A key transcription cofactor on the nascent sex chromosomes of European tree frogs (Hyla arborea)
Journal
Genetics
Author(s)
Niculita-Hirzel Hélène, Stöck M., Perrin N.
ISSN
0016-6731[print], 0016-6731[linking]
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
179
Number
3
Pages
1721-1723
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) within their glutamine-rich central part. These changes have the potential to affect the conformation of the Mediator complex and to activate genes in a sex-specific way and might thus represent the first steps toward the acquisition of a male-specific function. Alternatively, they might result from an ancestral neutral polymorphism, with different alleles picked by chance on the X and Y chromosomes when MED15 was trapped in the nonrecombining segment.
Keywords
Alleles, Animals, Conserved Sequence, Europe, Male, Ranidae/genetics, Sex Chromosomes/genetics, Transcription Factors/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
06/05/2008 7:18
Last modification date
20/08/2019 13:19
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