Effect of embryo culture media on birthweight and length in singleton term infants after IVF-ICSI.

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Version: Final published version
Serval ID
serval:BIB_333B02D0FD19
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of embryo culture media on birthweight and length in singleton term infants after IVF-ICSI.
Journal
Swiss Medical Weekly
Author(s)
Wunder D., Ballabeni P., Roth-Kleiner M., Primi M.P., Senn A., Chanson A., Germond M., Leyvraz C.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2014
Volume
144
Pages
w14038
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish
Abstract
QUESTIONS UNDER STUDY: To investigate if two distinct, commercially available embryo culture media have a different effect on birthweight and length of singleton term infants conceived after IVF-ICSI.
METHODS: University hospital based cohort study. Between 1 January 2000 and 31 December 2004, patients conceiving through IVF-ICSI at the University Hospital, Lausanne have been allocated to two distinct embryo culture media. Only term singleton pregnancies were analysed (n = 525). Data analysis was performed according to two commercially available culture media: Vitrolife (n = 352) versus Cook (n = 173). Analysis was performed through linear regression adjusted for confounders. Media were considered equivalent if the 95% confidence interval lay between -150 g/+150 g.
RESULTS: Length, gestational age and distribution of birthweight percentiles did not differ between groups (for both genders). Analysis of the whole cohort, adjusted for a subset of confounders, resulted in a statistically not different mean birthweight between the two groups (Vitrolife +37 g vs Cook, 95%CI: -46 g to 119 g) suggesting equivalence. Adjustment for an enlarged number of confounders in a subsample of patients (n = 258) also revealed no relevant mean birthweight difference of +71 g (95%CI: -45 g to 187 g) in favour of Vitrolife; however, lacking power to prove equivalence.
CONCLUSIONS: Our data suggest that significant differences in birthweight due to these two distinct, commercially available embryo culture media are unlikely.
Pubmed
Web of science
Open Access
Yes
Create date
13/11/2014 18:28
Last modification date
20/08/2019 13:19
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