[(18)F]FDG PET signal is driven by astroglial glutamate transport.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_326B11D79CDB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
[(18)F]FDG PET signal is driven by astroglial glutamate transport.
Journal
Nature neuroscience
Author(s)
Zimmer E.R., Parent M.J., Souza D.G., Leuzy A., Lecrux C., Kim H.I., Gauthier S., Pellerin L., Hamel E., Rosa-Neto P.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
03/2017
Peer-reviewed
Oui
Volume
20
Number
3
Pages
393-395
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [(18)F]FDG signal.
Keywords
Animals, Astrocytes/metabolism, Biological Transport, Brain/blood supply, Brain/drug effects, Brain/metabolism, Ceftriaxone/pharmacology, Cells, Cultured, Excitatory Amino Acid Transporter 1/agonists, Excitatory Amino Acid Transporter 1/physiology, Fluorodeoxyglucose F18/metabolism, Functional Neuroimaging, Glutamic Acid/metabolism, Locomotion/drug effects, Male, Positron-Emission Tomography, Rats, Vibrissae/physiology
URN
urn:nbn:ch:serval-BIB_326B11D79CDB7
OAI-PMH
oai:serval.unil.ch:BIB_326B11D79CDB
DOI
10.1038/nn.4492
Pubmed
28135241
Web of science
000394920400016
Create date
07/02/2017 19:19
Last modification date
30/04/2021 7:09
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