Substitution rates at neutral genes depend on population size under fluctuating demography and overlapping generations.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_2B87D605B70D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Substitution rates at neutral genes depend on population size under fluctuating demography and overlapping generations.
Journal
Evolution
Author(s)
Balloux F., Lehmann L.
ISSN
1558-5646 (Electronic)
ISSN-L
0014-3820
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
66
Number
2
Pages
605-611
Language
english
Abstract
It is widely accepted that the rate of evolution (substitution rate) at neutral genes is unaffected by population size fluctuations. This result has implications for the analysis of genetic data in population genetics and phylogenetics, and provides, in particular, a justification for the concept of the molecular clock. Here, we show that the substitution rate at neutral genes does depend on population size fluctuations in the presence of overlapping generations. As both population size fluctuations and overlapping generations are expected to be the norm rather than the exception in natural populations, this observation may be relevant for understanding variation in substitution rates within and between lineages.
Keywords
Demography, fixation rate, molecular clock, mutation rate, neutral theory
Pubmed
Web of science
Open Access
Yes
Create date
06/10/2011 17:18
Last modification date
20/08/2019 13:10
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