Cyclosporin A inhibits CD40 ligand expression in T lymphocytes

Details

Ressource 1Download: 7907604.pdf (1203.01 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_2B4B1FCE7C5D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cyclosporin A inhibits CD40 ligand expression in T lymphocytes
Journal
Journal of Clinical Investigation
Author(s)
Fuleihan R., Ramesh N., Horner A., Ahern D., Belshaw P. J., Alberg D. G., Stamenkovic I., Harmon W., Geha R. S.
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
93
Number
3
Pages
1315-1320
Language
english
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S
Abstract
The ligand for CD40 is expressed on activated T lymphocytes and delivers contact-dependent activation signals to B lymphocytes. The mechanisms regulating CD40 ligand gene expression are largely unknown. Optimal expression of CD40 ligand required activation of protein kinase C and a rise in intracellular calcium concentration. CD40 ligand expression was inhibited by pretreatment of T cells with cyclosporin A. Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. Cyclosporin A inhibited IL-4-driven CD40 ligand-dependent IgE isotype switching in PBMC but did not inhibit IgE synthesis induced by CD40 mAb plus IL-4. PBMC derived from transplant patients receiving cyclosporin A failed to express CD40 ligand upon stimulation. These results suggest that patients receiving cyclosporin A may be deficient in CD40 ligand-dependent T cell help
Keywords
Adolescent/Adult/CD40 Ligand/Calcineurin/Calmodulin-Binding Proteins/physiology/Child/Cyclosporine/pharmacology/Female/Humans/Immunoglobulin Class Switching/drug effects/Male/Membrane Glycoproteins/analysis/Phosphoprotein Phosphatase/Receptors,Interleukin-2/T-Lymphocytes/chemistry/Tetradecanoylphorbol Acetate/Research
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:35
Last modification date
20/08/2019 13:10
Usage data