Diffusion spectrum imaging shows the structural basis of functional cerebellar circuits in the human cerebellum in vivo.

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Serval ID
serval:BIB_2A0959E7B54C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diffusion spectrum imaging shows the structural basis of functional cerebellar circuits in the human cerebellum in vivo.
Journal
PloS One
Author(s)
Granziera Cristina, Schmahmann Jeremy Dan, Hadjikhani Nouchine, Meyer Heiko, Meuli Reto, Wedeen Van, Krueger Gunnar
ISSN
1932-6203[electronic]
Publication state
Published
Issued date
2009
Volume
4
Number
4
Pages
5101
Language
english
Abstract
BACKGROUND: The cerebellum is a complex structure that can be affected by several congenital and acquired diseases leading to alteration of its function and neuronal circuits. Identifying the structural bases of cerebellar neuronal networks in humans in vivo may provide biomarkers for diagnosis and management of cerebellar diseases. OBJECTIVES: To define the anatomy of intrinsic and extrinsic cerebellar circuits using high-angular resolution diffusion spectrum imaging (DSI). METHODS: We acquired high-resolution structural MRI and DSI of the cerebellum in four healthy female subjects at 3T. DSI tractography based on a streamline algorithm was performed to identify the circuits connecting the cerebellar cortex with the deep cerebellar nuclei, selected brainstem nuclei, and the thalamus. RESULTS: Using in-vivo DSI in humans we were able to demonstrate the structure of the following cerebellar neuronal circuits: (1) connections of the inferior olivary nucleus with the cerebellar cortex, and with the deep cerebellar nuclei (2) connections between the cerebellar cortex and the deep cerebellar nuclei, (3) connections of the deep cerebellar nuclei conveyed in the superior (SCP), middle (MCP) and inferior (ICP) cerebellar peduncles, (4) complex intersections of fibers in the SCP, MCP and ICP, and (5) connections between the deep cerebellar nuclei and the red nucleus and the thalamus. CONCLUSION: For the first time, we show that DSI tractography in humans in vivo is capable of revealing the structural bases of complex cerebellar networks. DSI thus appears to be a promising imaging method for characterizing anatomical disruptions that occur in cerebellar diseases, and for monitoring response to therapeutic interventions.
Keywords
Algorithms, Cerebellum/physiology, Female, Humans, Magnetic Resonance Imaging, Reference Values
Pubmed
Web of science
Open Access
Yes
Create date
08/04/2009 11:33
Last modification date
20/08/2019 13:09
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