Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging.

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Version: Final published version
Serval ID
serval:BIB_265D06B98C95
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging.
Journal
Neuroimage
Author(s)
Lambert C., Zrinzo L., Nagy Z., Lutti A., Hariz M., Foltynie T., Draganski B., Ashburner J., Frackowiak R.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
2012
Volume
60
Number
1
Pages
83-94
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor regions occupying the anterior, mid and posterior portions of the nucleus respectively. This study is the first to achieve in-vivo, non-invasive anatomical parcellation of the human STN into three anatomical zones within normal diagnostic scan times, which has important future implications for deep brain stimulation surgery.
Keywords
Adult, Brain Mapping, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Female, Humans, Male, Review Literature as Topic, Subthalamic Nucleus/anatomy & histology, Subthalamic Nucleus/physiology
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2012 19:07
Last modification date
20/08/2019 13:05
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