Astrocytes' Contribution to Adult Neurogenesis in Physiology and Alzheimer's Disease.

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State: Public
Version: author
Serval ID
serval:BIB_25F7A9967D59
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Astrocytes' Contribution to Adult Neurogenesis in Physiology and Alzheimer's Disease.
Journal
Frontiers in cellular neuroscience
Author(s)
Cassé F., Richetin K., Toni N.
ISSN
1662-5102 (Print)
ISSN-L
1662-5102
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
12
Pages
432
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression. Interestingly, adult neurogenesis is tightly regulated by the neurogenic niche, which provides a structural and molecular scaffold for stem cell proliferation and the differentiation and functional integration of new neurons. In this review, we highlight the role of astrocytes in the regulation of adult neurogenesis in the context of cognitive function. We also discuss how the changes in astrocytes function may dysregulate adult neurogenesis and contribute to cognitive impairment in the context of Alzheimer's disease.
Keywords
Alzheimer’s disease, astrocytes, neurogenesis, neurogenic niche, secretion
Pubmed
Web of science
Open Access
Yes
Create date
17/12/2018 9:08
Last modification date
20/08/2019 13:04
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