Depriving Mice of Sleep also Deprives of Food.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_2559BC56811B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Depriving Mice of Sleep also Deprives of Food.
Journal
Clocks & sleep
Author(s)
Đukanović N., La Spada F., Emmenegger Y., Niederhäuser G., Preitner F., Franken P.
ISSN
2624-5175 (Electronic)
ISSN-L
2624-5175
Publication state
Published
Issued date
11/02/2022
Peer-reviewed
Oui
Volume
4
Number
1
Pages
37-51
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Both sleep-wake behavior and circadian rhythms are tightly coupled to energy metabolism and food intake. Altered feeding times in mice are known to entrain clock gene rhythms in the brain and liver, and sleep-deprived humans tend to eat more and gain weight. Previous observations in mice showing that sleep deprivation (SD) changes clock gene expression might thus relate to altered food intake, and not to the loss of sleep per se. Whether SD affects food intake in the mouse and how this might affect clock gene expression is, however, unknown. We therefore quantified (i) the cortical expression of the clock genes Per1, Per2, Dbp, and Cry1 in mice that had access to food or not during a 6 h SD, and (ii) food intake during baseline, SD, and recovery sleep. We found that food deprivation did not modify the SD-incurred clock gene changes in the cortex. Moreover, we discovered that although food intake during SD did not differ from the baseline, mice lost weight and increased food intake during subsequent recovery. We conclude that SD is associated with food deprivation and that the resulting energy deficit might contribute to the effects of SD that are commonly interpreted as a response to sleep loss.
Keywords
body composition, circadian rhythms, clock genes, energy expenditure, fat, food intake, lean body mass, sleep deprivation
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2022 12:13
Last modification date
20/07/2022 7:08
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