EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disorders.

Details

Ressource 1Download: Veloza2021_Article_EBV-positiveLargeB-cellLymphom.pdf (1484.61 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_24812BA3BF72
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disorders.
Journal
Virchows Archiv
Author(s)
Veloza L., Tsai C.Y., Bisig B., Pantet O., Alberio L., Sempoux C., Cavassini M., de Leval L.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
480
Number
3
Pages
699-705
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Intravascular large B-cell lymphoma is a rare and aggressive EBV-negative large B-cell lymphoma with a dismal outcome. Here, we describe the case of a 76-year-old HIV-positive patient with an acute presentation of systemic symptoms and rapidly fatal outcome. Autopsy revealed a disseminated large B-cell lymphoma with an intravascular distribution involving the liver, lymph nodes, spleen, and bone marrow and associated to fibrin thrombi in hepatic capillary haemangiomas. The neoplastic B cells (CD79a + / - , CD20 + / - , CD30 + , MUM1 + , PD-L1 +) showed a Hodgkin and Reed-Sternberg-like morphology and were EBV-positive with a latency type II (LMP1 + , EBNA2-). Haemophagocytosis was documented in the bone marrow and lymph nodes. This case illustrates the diagnostic challenges of large B-cell lymphoma with intravascular presentation. We found only five other cases of EBV-positive large B-cell lymphoma with an intravascular presentation in the literature, three of which had an underlying immunodeficiency adding to the broad spectrum of EBV-associated lymphoma in the setting of immunosuppression.
Keywords
Aged, Epstein-Barr Virus Infections/complications, Epstein-Barr Virus Infections/pathology, HIV Infections/complications, Herpesvirus 4, Human, Humans, Lymphohistiocytosis, Hemophagocytic/complications, Lymphohistiocytosis, Hemophagocytic/etiology, Lymphoma, Large B-Cell, Diffuse/complications, Lymphoma, Large B-Cell, Diffuse/pathology, Lymphoproliferative Disorders/pathology, EBV, HIV, Haemophagocytic syndrome, Hepatic capillary haemangioma, Intravascular large B-cell lymphoma
Pubmed
Web of science
Open Access
Yes
Create date
21/06/2021 13:34
Last modification date
21/11/2022 8:08
Usage data