The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice.

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Serval ID
serval:BIB_1D7DED529F1F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice.
Journal
BMC Genetics
Author(s)
Wedekind C., Walker M., Little T.J.
ISSN
1471-2156[electronic], 1471-2156[linking]
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
7
Pages
55
Language
english
Abstract
BACKGROUND: The link between host MHC (major histocompatibility complex) genotype and malaria is largely based on correlative data with little or no experimental control of potential confounding factors. We used an experimental mouse model to test for main effects of MHC-haplotypes, MHC heterozygosity, and MHC x parasite clone interactions. We experimentally infected MHC-congenic mice (F2 segregants, homo- and heterozygotes, males and females) with one of two clones of Plasmodium chabaudi and recorded disease progression. RESULTS: We found that MHC haplotype and parasite clone each have a significant influence on the course of the disease, but there was no significant host genotype by parasite genotype interaction. We found no evidence for overdominance nor any other sort of heterozygote advantage or disadvantage. CONCLUSION: When tested under experimental conditions, variation in the MHC can significantly influence the course of malaria. However, MHC heterozygote advantage through overdominance or dominance of resistance cannot be assumed in the case of single-strain infections. Future studies might focus on the interaction between MHC heterozygosity and multiple-clone infections.
Keywords
Animals, Clone Cells, Disease Progression, Female, Genetic Predisposition to Disease, Genotype, H-2 Antigens/genetics, Haplotypes, Major Histocompatibility Complex/genetics, Malaria/genetics, Malaria/parasitology, Male, Mice, Mice, Congenic, Plasmodium chabaudi, Sex Factors
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:43
Last modification date
20/08/2019 12:53
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