Poly(ADP-ribose)polymerase inhibition decreases angiogenesis

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Serval ID
serval:BIB_1C8240AF20C3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Poly(ADP-ribose)polymerase inhibition decreases angiogenesis
Journal
Biochemical and Biophysical Research Communications
Author(s)
Rajesh M., Mukhopadhyay P., Godlewski G., Batkai S., Hasko G., Liaudet L., Pacher P.
ISSN
0006-291X (Print)
Publication state
Published
Issued date
12/2006
Peer-reviewed
Oui
Volume
350
Number
4
Pages
1056-62
Language
english
Notes
Journal Article
Research Support, N.I.H., Intramural --- Old month value: Dec 1
Abstract
Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation. We have recently demonstrated that PARP inhibition with 3-aminobenzamide or PJ-34 reduced vascular endothelial growth factor (VEGF)-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro. Here, we show dose-dependent reduction of VEGF- and basic fibroblast growth factor (bFGF)-induced proliferation, migration, and tube formation of HUVECs in vitro by two potent PARP inhibitors 5-aminoisoquinolinone-hydrochloride (5-AIQ) and 1,5-isoquinolinediol (IQD). Moreover, PARP inhibitors prevented the sprouting of rat aortic ring explants in an ex vivo assay of angiogenesis. These results establish the novel concept that PARP inhibitors have antiangiogenic effects, which may have tremendous clinical implications for the treatment of various cancers, tumor metastases, and certain retinopathies.
Keywords
Cell Movement/drug effects Cell Proliferation/drug effects Cells Cells, Cultured Dose-Response Relationship, Drug Endothelial Cells/drug effects/*physiology Humans Isoquinolines/*administration & dosage Neovascularization, Physiologic/drug effects/*physiology Poly(ADP-ribose) Polymerases/*antagonists & inhibitors Quinolines/administration & dosage
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Web of science
Create date
24/01/2008 17:01
Last modification date
20/08/2019 12:53
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