Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment.

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License: CC BY 4.0
Serval ID
serval:BIB_1B32BE187F04
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment.
Journal
International journal of molecular sciences
Author(s)
Jacovetti C., Regazzi R.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
14/02/2022
Peer-reviewed
Oui
Volume
23
Number
4
Pages
2096
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The functional maturation of insulin-secreting β-cells is initiated before birth and is completed in early postnatal life. This process has a critical impact on the acquisition of an adequate functional β-cell mass and on the capacity to meet and adapt to insulin needs later in life. Many cellular pathways playing a role in postnatal β-cell development have already been identified. However, single-cell transcriptomic and proteomic analyses continue to reveal new players contributing to the acquisition of β-cell identity. In this review, we provide an updated picture of the mechanisms governing postnatal β-cell mass expansion and the transition of insulin-secreting cells from an immature to a mature state. We then highlight the contribution of the environment to β-cell maturation and discuss the adverse impact of an in utero and neonatal environment characterized by calorie and fat overload or by protein deficiency and undernutrition. Inappropriate nutrition early in life constitutes a risk factor for developing diabetes in adulthood and can affect the β-cells of the offspring over two generations. A better understanding of these events occurring in the neonatal period will help developing better strategies to produce functional β-cells and to design novel therapeutic approaches for the prevention and treatment of diabetes.
Keywords
Animals, Animals, Newborn/metabolism, Animals, Newborn/physiology, Diabetes Mellitus/metabolism, Diabetes Mellitus/physiopathology, Humans, Infant, Newborn, Insulin/metabolism, Insulin-Secreting Cells/metabolism, Insulin-Secreting Cells/physiology, Nutritional Status/physiology, embryonic nutritional deficiency, in utero and postnatal obese environment, postnatal β-cell development, transgenerational metabolic disorders, β-cell maturation, β-cell proliferation
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2022 11:39
Last modification date
21/11/2022 8:19
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