Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_17EF0CA720D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts.
Journal
Translational psychiatry
Author(s)
Pistis G., Milaneschi Y., Vandeleur C.L., Lasserre A.M., Penninx BWJH, Lamers F., Boomsma D.I., Hottenga J.J., Marques-Vidal P., Vollenweider P., Waeber G., Aubry J.M., Preisig M., Kutalik Z.
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Publication state
Published
Issued date
04/02/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
96
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Studies considering the causal role of body mass index (BMI) for the predisposition of major depressive disorder (MDD) based on a Mendelian Randomization (MR) approach have shown contradictory results. These inconsistent findings may be attributable to the heterogeneity of MDD; in fact, several studies have documented associations between BMI and mainly the atypical subtype of MDD. Using a MR approach, we investigated the potential causal role of obesity in both the atypical subtype and its five specific symptoms assessed according to the Statistical Manual of Mental Disorders (DSM), in two large European cohorts, CoLaus|PsyCoLaus (n = 3350, 1461 cases and 1889 controls) and NESDA|NTR (n = 4139, 1182 cases and 2957 controls). We first tested general obesity measured by BMI and then the body fat distribution measured by waist-to-hip ratio (WHR). Results suggested that BMI is potentially causally related to the symptom increase in appetite, for which inverse variance weighted, simple median and weighted median MR regression estimated slopes were 0.68 (SE = 0.23, p = 0.004), 0.77 (SE = 0.37, p = 0.036), and 1.11 (SE = 0.39, p = 0.004). No causal effect of BMI or WHR was found on the risk of the atypical subtype or for any of the other atypical symptoms. Our findings show that higher obesity is likely causal for the specific symptom of increase in appetite in depressed participants and reiterate the need to study depression at the granular level of its symptoms to further elucidate potential causal relationships and gain additional insight into its biological underpinnings.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 105993
Swiss National Science Foundation / 118308
Swiss National Science Foundation / 122661
Swiss National Science Foundation / 139468
Swiss National Science Foundation / 148401
Swiss National Science Foundation / 177535
Create date
11/02/2021 11:23
Last modification date
30/04/2021 6:08
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