Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.

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Serval ID
serval:BIB_17206
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.
Journal
The Journal of Experimental Medicine
Author(s)
Tenan M., Fulci G., Albertoni M., Diserens A.C., Hamou M.F., El Atifi-Borel M., Feige J.J., Pepper M.S., Van Meir E.G.
ISSN
0022-1007
Publication state
Published
Issued date
2000
Volume
191
Number
10
Pages
1789-1798
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Abstract
Angiogenesis, the sprouting of new capillaries from preexisting blood vessels, results from a disruption of the balance between stimulatory and inhibitory factors. Here, we show that anoxia reduces expression of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, in glioblastoma cells. This suggests that reduced oxygen tension can promote angiogenesis not only by stimulating the production of inducers, such as vascular endothelial growth factor, but also by reducing the production of inhibitors. This downregulation may significantly contribute to glioblastoma development, since we show that an increase in TSP-1 expression is sufficient to strongly suppress glioblastoma cell tumorigenicity in vivo.
Keywords
Animals, Anoxia/genetics, Anoxia/physiopathology, Base Sequence, DNA Primers/genetics, Down-Regulation, Genes, p53, Glioblastoma/blood supply, Glioblastoma/genetics, Humans, Male, Mice, Mice, Nude, Neoplasm Transplantation, Neovascularization, Pathologic/genetics, RNA, Messenger/genetics, RNA, Messenger/metabolism, RNA, Neoplasm/genetics, RNA, Neoplasm/metabolism, Thrombospondin 1/biosynthesis, Thrombospondin 1/genetics, Transplantation, Heterologous, Tumor Cells, Cultured
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Web of science
Create date
19/11/2007 12:10
Last modification date
20/08/2019 12:46
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