Host response to fungal infections - how immunology and host genetics could help to identify and treat patients at risk.

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Ressource 1Download: 27655228.pdf (780.55 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_1594C7A7A8E7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Host response to fungal infections - how immunology and host genetics could help to identify and treat patients at risk.
Journal
Swiss medical weekly
Author(s)
Khanna N., Stuehler C., Lünemann A., Wójtowicz A., Bochud P.Y., Leibundgut-Landmann S.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
146
Pages
w14350
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In spite of the ever-increasing incidence and poor outcome of invasive fungal infections in immune compromised patients, there is currently no reliable method to accurately predict the risk, to monitor the outcome and to treat these infections. Protective immunity against Candida and Aspergillus depends on a highly coordinated interaction between the innate and adaptive immune systems. Genetic and immunological defects in components of these networks result in increased risk of invasive fungal infections among patients undergoing chemotherapy or transplant recipients. We review the most important genetic and immunological factors that influence human susceptibility to Candida and Aspergillus infections and discuss the potential role of basic research to promote precision medicine for infectious diseases. We discuss how immunogenetic studies can help to provide tools for improved identification of high-risk patients and the development of tailored antifungal therapies.

Pubmed
Web of science
Open Access
Yes
Create date
29/09/2016 18:46
Last modification date
20/08/2019 12:44
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