Quantitative genetics of sleep in inbred mice.

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Serval ID
serval:BIB_11C27EA6C67D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Quantitative genetics of sleep in inbred mice.
Journal
Dialogues in Clinical Neuroscience
Author(s)
Tafti M.
ISSN
1294-8322[print]
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
9
Number
3
Pages
273-278
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The timing and the organization of sleep architecture are mainly controlled by the circadian system, while sleep need and intensity are regulated by a homeostatic process. How independent these two systems are in regulating sleep is not well understood. In contrast to the impressive progress in the molecular genetics of circadian rhythms, little is known about the molecular basis of sleep. Nevertheless, as summarized here, phenotypic dissection of sleep into its most basic aspects can be used to identify both the single major genes and small effect quantitative trait loci involved. Although experimental models such as the mouse are more readily amenable to genetic analysis of sleep, similar approaches can be applied to humans.
Keywords
Animals, Circadian Rhythm/genetics, Electroencephalography/methods, Gene Expression Regulation/physiology, Mice, Mice, Inbred Strains/physiology, Quantitative Trait Loci, Sleep/genetics
Pubmed
Create date
24/01/2008 15:55
Last modification date
20/08/2019 12:39
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