Patterns of Carbon-Bound Exogenous Compounds in Patients with Lung Cancer and Association with Disease Pathophysiology.

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_10B46795FCEE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Patterns of Carbon-Bound Exogenous Compounds in Patients with Lung Cancer and Association with Disease Pathophysiology.
Journal
Cancer research
Author(s)
Kunzke T., Prade V.M., Buck A., Sun N., Feuchtinger A., Matzka M., Fernandez I.E., Wuyts W., Ackermann M., Jonigk D., Aichler M., Schmid R.A., Eickelberg O., Berezowska S., Walch A.
ISSN
1538-7445 (Electronic)
ISSN-L
0008-5472
Publication state
Published
Issued date
01/12/2021
Peer-reviewed
Oui
Volume
81
Number
23
Pages
5862-5875
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Asymptomatic anthracosis is the accumulation of black carbon particles in adult human lungs. It is a common occurrence, but the pathophysiologic significance of anthracosis is debatable. Using in situ high mass resolution matrix-assisted laser desorption/ionization (MALDI) fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging analysis, we discovered noxious carbon-bound exogenous compounds, such as polycyclic aromatic hydrocarbons (PAH), tobacco-specific nitrosamines, or aromatic amines, in a series of 330 patients with lung cancer in highly variable and unique patterns. The characteristic nature of carbon-bound exogenous compounds had a strong association with patient outcome, tumor progression, the tumor immune microenvironment, programmed death-ligand 1 (PD-L1) expression, and DNA damage. Spatial correlation network analyses revealed substantial differences in the metabolome of tumor cells compared with tumor stroma depending on carbon-bound exogenous compounds. Overall, the bioactive pool of exogenous compounds is associated with several changes in lung cancer pathophysiology and correlates with patient outcome. Given the high prevalence of anthracosis in the lungs of adult humans, future work should investigate the role of carbon-bound exogenous compounds in lung carcinogenesis and lung cancer therapy. SIGNIFICANCE: This study identifies a bioactive pool of carbon-bound exogenous compounds in patient tissues associated with several tumor biological features, contributing to an improved understanding of drivers of lung cancer pathophysiology.
Keywords
Carcinogenesis, Carcinoma, Squamous Cell/chemically induced, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/pathology, Humans, Idiopathic Pulmonary Fibrosis/chemically induced, Idiopathic Pulmonary Fibrosis/metabolism, Idiopathic Pulmonary Fibrosis/pathology, Lung Neoplasms/chemically induced, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Mass Spectrometry, Metabolome, Nitrosamines/adverse effects, Polycyclic Aromatic Hydrocarbons/adverse effects, Retrospective Studies, Tobacco Use, Tumor Microenvironment
Pubmed
Web of science
Create date
25/10/2021 8:19
Last modification date
21/11/2022 8:19
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