Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_0FB506A88F16
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions.
Journal
International journal of molecular sciences
Author(s)
Brozzi F., Regazzi R.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
03/02/2021
Peer-reviewed
Oui
Volume
22
Number
4
Pages
1503
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Circular RNAs (circRNAs) constitute a large class of non-coding RNAs characterized by a covalently closed circular structure. They originate during mRNA maturation through a modification of the splicing process and, according to the included sequences, are classified as Exonic, Intronic, or Exonic-Intronic. CircRNAs can act by sequestering microRNAs, by regulating the activity of specific proteins, and/or by being translated in functional peptides. There is emerging evidence indicating that dysregulation of circRNA expression is associated with pathological conditions, including cancer, neurological disorders, cardiovascular diseases, and diabetes. The aim of this review is to provide a comprehensive and updated view of the most abundant circRNAs expressed in pancreatic islet cells, some of which originating from key genes controlling the differentiation and the activity of insulin-secreting cells or from diabetes susceptibility genes. We will particularly focus on the role of a group of circRNAs that contribute to the regulation of β-cell functions and that display altered expression in the islets of rodent diabetes models and of type 2 diabetic patients. We will also provide an outlook of the unanswered questions regarding circRNA biology and discuss the potential role of circRNAs as biomarkers for β-cell demise and diabetes development.
Keywords
diabetes, insulin, non-coding RNA, pancreatic islet
Pubmed
Open Access
Yes
Create date
22/02/2021 14:53
Last modification date
25/02/2022 7:08
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