R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers
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State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_0A09E75EECE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers
Journal
American Journal of Hypertension
ISSN
0895-7061 (Print)
Publication state
Published
Issued date
04/1994
Volume
7
Number
4 Pt 1
Pages
295-301
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Abstract
The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 micrograms/min/kg body wt) reduced blood pressure in a dose-dependent fashion; the mean arterial blood pressure at the end of the infusion fell from 128 +/- 4/83 +/- 4 to 119 +/- 3/71 +/- 3 mm Hg (mean +/- SEM) (P < .01) during the low sodium intake diet. R-PEP-27 had no effect on blood pressure during the high sodium intake diet. R-PEP-27 significantly reduced plasma angiotensin II and aldosterone concentrations. The temporal response to R-PEP-27 suggests that it is a short-lived although highly potent competitive inhibitor of renin; this peptide is a valuable and specific physiologic probe of the renin-angiotensin system.
Keywords
Adult
Aldosterone/blood
Angiotensin II/*blood
Blood Pressure/*drug effects
Female
Homeostasis
Humans
Male
Middle Aged
Oligopeptides/adverse effects/*pharmacology
Osmolar Concentration
Reference Values
Renin/*antagonists & inhibitors
Urine/chemistry
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 17:41
Last modification date
14/02/2022 8:53