Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations.

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Serval ID
serval:BIB_08FFB623B3A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations.
Journal
European Journal of Epidemiology
Author(s)
Rossi I.A., Bochud M., Bovet P., Paccaud F., Waeber G., Vollenweider P., Taffé P.
ISSN
1573-7284 (Electronic)
ISSN-L
0393-2990
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
27
Number
5
Pages
379-384
Language
english
Notes
Publication types: Journal Article
Abstract
Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated and correlations are stronger in women than men. We used fractional polynomials-a method that allows flexible modeling of non linear relations-to investigate the dose/response mathematical relationship between hs-CRP and several indicators of adiposity in Caucasians (Switzerland) and Africans (Seychelles) surveyed in two population-based studies. This relationship was non-linear exhibiting a steeper slope for low levels of hs-CRP and a higher level in women. The observed sex difference in the relationship between hs-CRP and adiposity almost disappeared upon adjustment for leptin, suggesting that these sex differences might be partially mediated, by leptin. All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity.
Pubmed
Web of science
Create date
02/05/2012 14:26
Last modification date
20/08/2019 12:31
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