A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.

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Ressource 1Download: Cancers_2016.pdf (575.32 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_0657B56ECED9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.
Journal
Cancers
Author(s)
Ahmed K., Shaw H.V., Koval A., Katanaev V.L.
ISSN-L
2072-6694
Publication state
Published
Issued date
14/07/2016
Volume
8
Number
7
Pages
1-27
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers. Despite the urgent need, no WNT signaling-directed drugs currently exist, and only very few candidates have reached early phase clinical trials. Among different strategies to develop WNT-targeting anti-cancer therapies, repositioning of existing drugs previously approved for other diseases is a promising approach. Nonsteroidal anti-inflammatory drugs like aspirin, the anti-leprotic clofazimine, and the anti-trypanosomal suramin are among examples of drugs having recently revealed WNT-targeting activities. In total, 16 human-use drug compounds have been found to be working through the WNT pathway and show promise for their prospective repositioning against various cancers. Advances, hurdles, and prospects of developing these molecules as potential drugs against WNT-dependent cancers, as well as approaches for discovering new ones for repositioning, are the foci of the current review.

Pubmed
Web of science
Open Access
Yes
Create date
20/12/2016 16:32
Last modification date
17/09/2020 8:18
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