Gliotransmitters travel in time and space.

Details

Ressource 1Download: BIB_028C9626FD9E.P001.pdf (763.64 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_028C9626FD9E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gliotransmitters travel in time and space.
Journal
Neuron
Author(s)
Araque A., Carmignoto G., Haydon P.G., Oliet S.H., Robitaille R., Volterra A.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
81
Number
4
Pages
728-739
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.
Keywords
Animals, Astrocytes/physiology, Cell Communication/physiology, Humans, Neuronal Plasticity/physiology, Neurons/physiology, Synapses/metabolism, Synaptic Transmission/physiology
Pubmed
Web of science
Open Access
Yes
Create date
31/10/2016 14:32
Last modification date
20/08/2019 12:24
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