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doi:10.22028/D291-35797
Titel: | Quantification of periaortic adipose tissue in contrast-enhanced CT angiography: technical feasibility and methodological considerations |
VerfasserIn: | Mamopoulos, Apostolos T. Freyhardt, Patrick Touloumtzidis, Aristotelis Zapenko, Alexander Katoh, Marcus Gäbel, Gabor |
Sprache: | Englisch |
Titel: | The International Journal of Cardiovascular Imaging |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Periaortic fat tissue Abdominal aortic aneurysm Periaortic adipocytes Aneurysm progression |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | To examine the feasibility of the quantifcation of abdominal periaortic fat tissue (PaFT) (tissue within − 45 to − 195 HU) in enhanced CT-angiographies compared to unenhanced CT-scans and identify methodological issues afecting its clinical implementation. Using OsirixMD, PaFT volume and mean HU value were retrospectively measured within a 5 mm periaortic ring in paired unenhanced and enhanced abdominal aortic CT-scans. The correlation between PaFT values was examined in a derivation cohort (n=101) and linear regression analysis produced correction factors to convert values from enhanced into values from unenhanced CTs. The conversion factors were then applied to enhanced CTs in a diferent validation cohort (n=47) and agreement of corrected enhanced values with values from unenhanced scans was evaluated. Correlation between PaFT Volume und Mean HU from enhanced and unenhanced scans was very high (r >0.99 and r=0.95, respectively, p<0.0001 for both). The correction factors for PaFT Volume and Mean HU were 1.1057 and 1.0011. Potential confounding factors (CT-kilovoltage, slice thickness, mean intraluminal contrast density, aortic wall calcifcation, longitudinal variation of intraluminal contrast density, aortic diameter) showed no signifcant efect in a multivariate regression analysis (p>0.05). Bland-Altman analysis of corrected enhanced and unenhanced values showed excellent agreement and Passing–Bablok regression confrmed minimal/no residual bias. PaFT can be quantifed in enhanced CT-angiographies very reliably. PaFT Volume scores are very consistently slightly underestimated in enhanced scans by about 10%, while the PaFT Mean HU value remains practically constant and ofers distinct methodological advantages. However, a number of methodological issues remain to be addressed. |
DOI der Erstveröffentlichung: | 10.1007/s10554-022-02561-8 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-357974 hdl:20.500.11880/32640 http://dx.doi.org/10.22028/D291-35797 |
ISSN: | 1573-0743 1569-5794 |
Datum des Eintrags: | 18-Mär-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM3_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM4_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM5_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM6_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM7_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM8_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM9_ESM.pdf https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM10_ESM.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Mamopoulos2022_Article_QuantificationOfPeriaorticAdip.pdf | 7,33 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons