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Titel: Quantification of periaortic adipose tissue in contrast-enhanced CT angiography: technical feasibility and methodological considerations
VerfasserIn: Mamopoulos, Apostolos T.
Freyhardt, Patrick
Touloumtzidis, Aristotelis
Zapenko, Alexander
Katoh, Marcus
Gäbel, Gabor
Sprache: Englisch
Titel: The International Journal of Cardiovascular Imaging
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2022
Freie Schlagwörter: Periaortic fat tissue
Abdominal aortic aneurysm
Periaortic adipocytes
Aneurysm progression
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: To examine the feasibility of the quantifcation of abdominal periaortic fat tissue (PaFT) (tissue within − 45 to − 195 HU) in enhanced CT-angiographies compared to unenhanced CT-scans and identify methodological issues afecting its clinical implementation. Using OsirixMD, PaFT volume and mean HU value were retrospectively measured within a 5 mm periaortic ring in paired unenhanced and enhanced abdominal aortic CT-scans. The correlation between PaFT values was examined in a derivation cohort (n=101) and linear regression analysis produced correction factors to convert values from enhanced into values from unenhanced CTs. The conversion factors were then applied to enhanced CTs in a diferent validation cohort (n=47) and agreement of corrected enhanced values with values from unenhanced scans was evaluated. Correlation between PaFT Volume und Mean HU from enhanced and unenhanced scans was very high (r >0.99 and r=0.95, respectively, p<0.0001 for both). The correction factors for PaFT Volume and Mean HU were 1.1057 and 1.0011. Potential confounding factors (CT-kilovoltage, slice thickness, mean intraluminal contrast density, aortic wall calcifcation, longitudinal variation of intraluminal contrast density, aortic diameter) showed no signifcant efect in a multivariate regression analysis (p>0.05). Bland-Altman analysis of corrected enhanced and unenhanced values showed excellent agreement and Passing–Bablok regression confrmed minimal/no residual bias. PaFT can be quantifed in enhanced CT-angiographies very reliably. PaFT Volume scores are very consistently slightly underestimated in enhanced scans by about 10%, while the PaFT Mean HU value remains practically constant and ofers distinct methodological advantages. However, a number of methodological issues remain to be addressed.
DOI der Erstveröffentlichung: 10.1007/s10554-022-02561-8
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-357974
hdl:20.500.11880/32640
http://dx.doi.org/10.22028/D291-35797
ISSN: 1573-0743
1569-5794
Datum des Eintrags: 18-Mär-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Information
In Beziehung stehendes Objekt: https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM1_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM3_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM4_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM5_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM6_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM7_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM8_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM9_ESM.pdf
https://static-content.springer.com/esm/art%3A10.1007%2Fs10554-022-02561-8/MediaObjects/10554_2022_2561_MOESM10_ESM.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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