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doi:10.22028/D291-27443
Titel: | Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design |
VerfasserIn: | Estevam, Ethiene Castellucci Witek, Karolina Faulstich, Lisa Nasim, Muhammad Jawad Latacz, Gniewomir Domínguez-Álvarez, Enrique Kieć-Kononowicz, Katarzyna Demasi, Marilene Handzlik, Jadwiga Jacob, Claus |
Sprache: | Englisch |
Titel: | Molecules |
Bandnummer: | 20 |
Heft: | 8 |
Startseite: | 13894 |
Endseite: | 13912 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2015 |
DDC-Sachgruppe: | 540 Chemie |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Selenium is traditionally considered as an antioxidant element and selenium compounds are often discussed in the context of chemoprevention and therapy. Recent studies, however, have revealed a rather more colorful and diverse biological action of selenium-based compounds, including the modulation of the intracellular redox homeostasis and an often selective interference with regulatory cellular pathways. Our basic activity and mode of action studies with simple selenium and tellurium salts in different strains of Staphylococcus aureus (MRSA) and Saccharomyces cerevisiae indicate that such compounds are sometimes not particularly toxic on their own, yet enhance the antibacterial potential of known antibiotics, possibly via the bioreductive formation of insoluble elemental deposits. Whilst the selenium and tellurium compounds tested do not necessarily act via the generation of Reactive Oxygen Species (ROS), they seem to interfere with various cellular pathways, including a possible inhibition of the proteasome and hindrance of DNA repair. Here, organic selenides are considerably more active compared to simple salts. The interference of selenium (and tellurium) compounds with multiple targets could provide new avenues for the development of effective antibiotic and anticancer agents which may go well beyond the traditional notion of selenium as a simple antioxidant. |
DOI der Erstveröffentlichung: | 10.3390/molecules200813894 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-274435 hdl:20.500.11880/28537 http://dx.doi.org/10.22028/D291-27443 |
ISSN: | 1420-3049 |
Datum des Eintrags: | 6-Jan-2020 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Pharmazie |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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molecules-20-13894.pdf | 1,47 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons