Development of Photo-Induced C–H Activation by Copper and Ruthenium Catalysis
von Julian Koeller
Datum der mündl. Prüfung:2019-10-29
Erschienen:2019-11-08
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Konrad Koszinowski
Gutachter:Prof. Dr. Dr. Lutz Tietze
Gutachter:Prof. Dr. Dietmar Stalke
Gutachter:Dr. Holm Frauendorf
Gutachter:Dr. Michael John
Dateien
Name:Dissertation_J_Koeller.pdf
Size:18.2Mb
Format:PDF
Zusammenfassung
Englisch
Within recent decades, transition metal-catalyzed C–H activation has become a valuable and versatile tool for organic synthesis. As C–H bonds are ubiquitous in organic molecules, the direct site-selective functionalization of C–H bonds can avoid pre-functionalization and thereby enhances the step- and atom economy of the synthesis. This thesis illustrates the use of earth-abundant and cost-effective copper catalysts for the facile C–H chalcogenation of indolines and indoles. By merging transition metal catalysis with photocatalysis, inexpensive copper catalysts could also be employed for the C–H arylation of azoles at ambient temperature. This concept of photo-induced C–H activation was also applied to the meta-selective ruthenium-catalyzed C–H alkylation.
Keywords: arylation; ruthenium; photocatalysis; meta-selective alkylation; chalcogenation; C–H activation; copper; transition metal catalysis; photo-induced