@article{Schneider2004Perio-6964,
  year={2004},
  title={Perioperative Recombinant Human Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Prevents Immunoinflammatory Dysfunction Associated With Major Surgery},
  number={1},
  volume={239},
  journal={Annals of surgery},
  pages={75--81},
  author={Schneider, Christian and Aulock, Sonja von and Zedler, Siegfried and Schinkel, Christian and Hartung, Thomas and Faist, Eugen}
}

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    <dcterms:abstract xml:lang="eng">Objective: To examine the effects of perioperative rhG-CSF administration on immune function in patients subjected to major surgery.&lt;br /&gt;&lt;br /&gt;Summary Background Data: Severe trauma, such as major surgery, initiates acute immunodysfunction which predisposes the patient towards infectious complications.&lt;br /&gt;&lt;br /&gt;Methods: Sixty patients undergoing elective surgery received either recombinant human granulocyte colony-stimulating factor/rh G-CSF (Filgrastim) or a placebo perioperatively. At several time points before and after the surgical intervention immunofunctional parameters were assessed.&lt;br /&gt;&lt;br /&gt;Results: Leukocyte counts and serum levels of anti-inflammatory mediators (IL-1ra and TNF-R) were increased in Filgrastim-treated patients, while the post-operative acute phase response was attenuated. Monocyte deactivation (reduced TNF-α release and HLA-DR expression) and lymphocyte anergy (impaired mitogenic proliferation and reduced TH1 lymphokine release) were blunted and the incidence and severity of infectious complications were reduced.&lt;br /&gt;&lt;br /&gt;Conclusions: These results suggest that Filgrastim treatment reinforces innate immunity, enabling better prevention of infection. Thus, this unique combination of hematopoietic, anti-inflammatory and anti-infectious effects on the innate immune system warrants further study of clinical efficacy and sepsis prophylaxis.</dcterms:abstract>
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    <dc:contributor>Schinkel, Christian</dc:contributor>
    <dcterms:issued>2004</dcterms:issued>
    <dc:creator>Zedler, Siegfried</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Annals of surgery 239 (2004), 1, pp. 75-81</dcterms:bibliographicCitation>
    <dc:creator>Hartung, Thomas</dc:creator>
    <dc:contributor>Faist, Eugen</dc:contributor>
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    <dcterms:title>Perioperative Recombinant Human Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Prevents Immunoinflammatory Dysfunction Associated With Major Surgery</dcterms:title>
    <dc:creator>Schneider, Christian</dc:creator>
    <dc:contributor>Hartung, Thomas</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:30:29Z</dc:date>
    <dc:contributor>Aulock, Sonja von</dc:contributor>
    <dc:creator>Schinkel, Christian</dc:creator>
    <dc:contributor>Zedler, Siegfried</dc:contributor>
    <dc:creator>Aulock, Sonja von</dc:creator>
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