- AutorIn
- Rebecca Kuepper
- Jim Van Os
- Roselind Lieb
- Hans-Ulrich Wittchen
- Cécile Henquet
- Titel
- Do cannabis and urbanicity co-participate in causing psychosis? Evidence from a 10-year follow-up cohort study
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-103747
- Quellenangabe
- Psychological Medicine, Bd. 41 (2011), Nr.10, S. 2121-2129, ISSN: 0033-2917
- Erstveröffentlichung
- 2011
- Abstract (EN)
- Background: Cannabis use is considered a component cause of psychotic illness, interacting with genetic and other environmental risk factors. Little is known, however, about these putative interactions. The present study investigated whether an urban environment plays a role in moderating the effects of adolescent cannabis use on psychosis risk. Method: Prospective data (n=1923, aged 14–24 years at baseline) from the longitudinal population-based German Early Developmental Stages of Psychopathology cohort study were analysed. Urbanicity was assessed at baseline and defined as living in the city of Munich (1562 persons per km2; 4061 individuals per square mile) or in the rural surroundings (213 persons per km2; 553 individuals per square mile). Cannabis use and psychotic symptoms were assessed three times over a 10-year follow-up period using the Munich version of the Composite International Diagnostic Interview. Results: Analyses revealed a significant interaction between cannabis and urbanicity [10.9% adjusted difference in risk, 95% confidence interval (CI) 3.2–18.6, p=0.005]. The effect of cannabis use on follow-up incident psychotic symptoms was much stronger in individuals who grew up in an urban environment (adjusted risk difference 6.8%, 95% CI 1.0–12.5, p=0.021) compared with individuals from rural surroundings (adjusted risk difference −4.1%, 95% CI −9.8 to 1.6, p=0.159). The statistical interaction was compatible with substantial underlying biological synergism. Conclusions: Exposure to environmental influences associated with urban upbringing may increase vulnerability to the psychotomimetic effects of cannabis use later in life.
- Andere Ausgabe
- DOI: 10.1017/S0033291711000511
- Link zur Originalpublikation, welcher zuerst in der Zeitschrift Psychological Medicine bei Cambridge University Press erschienen ist
Link: http://dx.doi.org/10.1017/S0033291711000511 - Freie Schlagwörter (DE)
- Cannabis, Kohortenstudie, Interaktion, Psychose, städtisches Umfeld
- Freie Schlagwörter (EN)
- Cannabis, cohort study, interaction, psychosis, urban environment
- Klassifikation (DDC)
- 150
- Klassifikation (RVK)
- CW 6940, CU 3000
- Verlag
- Cambridge University Press, Cambridge, UK
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-103747
- Veröffentlichungsdatum Qucosa
- 30.01.2013
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis