A whole-genome association study of major determinants for host control of HIV-1

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Serval ID
serval:BIB_FF4BA16623BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A whole-genome association study of major determinants for host control of HIV-1
Journal
Science
Author(s)
Fellay J., Shianna K. V., Ge D., Colombo S., Ledergerber B., Weale M., Zhang K., Gumbs C., Castagna A., Cossarizza A., Cozzi-Lepri A., De Luca A., Easterbrook P., Francioli P., Mallal S., Martinez-Picado J., Miro J. M., Obel N., Smith J. P., Wyniger J., Descombes P., Antonarakis S. E., Letvin N. L., McMichael A. J., Haynes B. F., Telenti A., Goldstein D. B.
ISSN
1095-9203 (Electronic)
Publication state
Published
Issued date
08/2007
Peer-reviewed
Oui
Volume
317
Number
5840
Pages
944-947
Language
english
Notes
Journal Article Multicenter Study Research Support, Non-U.S. Gov't --- Old month value: Aug 17
Abstract
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Keywords
Cohort Studies DNA-Binding Proteins/genetics Disease Progression Female Genes, MHC Class I *Genome, Human HIV Infections/*genetics/immunology/therapy/*virology HIV-1/*physiology HLA-B Antigens/*genetics HLA-C Antigens/*genetics Haplotypes Humans Immediate-Early Proteins/genetics Major Histocompatibility Complex/*genetics Male Polymorphism, Single Nucleotide Regression Analysis Viral Load
Pubmed
Web of science
Create date
25/01/2008 17:08
Last modification date
20/08/2019 16:29
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